Dr. Lindsay Parker
Please see each link for full details of all publications and presentations.
Contributions to Science
Early Career: During my early career I worked with a team of graduate students who were investigating sympathetic ganglia and heart tissues in normal rats with regional sympathetic nerve destruction or rats with DOCA-salt hypertension. In one of our publications we were able to demonstrate in hypertensive rats that a protein producing superoxide is regulated in opposite directions in sympathetic neurons and sensory neurons. In another publication I helped describe the differential regional expression of norepinephrine transporter protein across heart chambers. I additionally conducted my own independent research studying cardiovascular responses in a hypertensive model of rats that overexpress endothelin B receptors selectively in their sympathetic nervous system.
Graduate Career: I produced several first author publications during my graduate career on molecular mechanisms contributing to hypertension and hypoglycemia. My graduate research helped to identify specific neurochemical codes of brainstem and spinal cord neurons that regulate adrenal gland release of adrenaline and noradrenaline in response to lowering blood glucose drastically. I additionally studied the distribution of Gα protein mRNAs in the brainstem and adrenal glands of rats with neurogenic hypertension and found an increase in excitatory Gα subunit mRNA in these regions suggesting increased excitatory neuropeptide signaling in blood pressure regulating neurons.
Postdoctoral Career: In my post-doctoral career I have discovered that spinal cord neurons regulating blood glucose or blood pressure have district neurochemical codes. I have contributed to publications describing protein changes during neuronal differentiation and in ground state pluripotency. I have also trained graduate students and assisted them in analyzing molecular changes in the rat prefrontal cortex, nucleus accumbens and subthalamic nucleus following self-administered methamphetamines. I have developed new ISH techniques using nanodiamonds and europium lanthanide conjugates. Currently I am working on developing nanobiotechnology based tools for targeting sugar receptors on the surface of brain cells in chronic pain and brain cancer.