Home   Education   Experience   Publications   Affiliations   Contact

Lindsay M Parker

About

b1

My key research interest has always been to improve our understanding of neural circuitry, neuronal gene expression and neuronal behavior during acute or chronic stressors. I have long held a personal interest in researching cardiovascular disease as I was diagnosed in my teens with an inherited neurogenic cardiovascular disorder and my father died at a young age from cardiovascular disease. My academic experience and research training have provided me the opportunity to understand, in depth, cardiovascular disease progression and the effects of multiple other types of physiological stressors at the systems and cellular levels in the central and peripheral nervous systems. I currently have 12 peer reviewed publications and several more under review in this field. As an undergraduate student I was highly interested in understanding how stress hormones affect the brain to produce behavioral outcomes in animals and humans. I then worked for two years under Professors David Kreulen and Gregory Fink examining molecular changes in autonomic ganglia during hypertension. I completed my graduate research with Associate Professor Ann Goodchild understanding molecular mechanisms that contribute to hypertension, hypotension, hypoglycemia and hyperglycemia. Specifically, I used cholera toxin B neuronal tracing in combination with in situ hybridization and immunohistochemistry for neurochemical markers. During the next two years as a post doc I continued researching hypothalamic pituitary axis responses to physiological stressors including describing hyperglycemic responses to common medications prescribed for the treatment of hypertension. I have been complimented many times by reviewers in papers and by all of my three thesis reviewers for undertaking technically challenging and impressive work in the field of neuronal tracing and in situ hybridization/ immunohistochemical techniques. I additionally have collaborated on a number of studies looking at molecular mechanisms involved in the development and extinction of methamphetamine addiction as well as neurochemical identification of circuits regulating brainstem respiratory responses. My work directly contributed to one publication being featured as the journal cover image for its issue. I have presented my findings at multiple domestic and international conferences and I have trained and/or supervised a number of students at the undergraduate, masters and Ph.D. levels. I also ran the biomedical imaging facility within my department as a post doc, training and managing more than 100 people in our facility, and was instrumental in the success of our department obtaining >$450,000 in funding towards the purchase of a new high end confocal microscope. My current post doc position enables me to facilitate multidisciplinary approaches for studying biological challenges by using innovative novel technologies to enhance imaging capabilities- making nanoparticles and advanced microscopy techniques understandable and accessible to neuroscientists and other biologists. This includes integrating the latest advancements from the fields of microfluidics, biophysics, materials chemistry and photonics to help neuroscientists solve common challenges presented when imaging brain and spinal cord tissues.

Publications

Novel imaging tools for investigating the role of immune signaling in the brain

Jacobsen JHW, Parker LM, Staikopoulos V, Schartner E, Tsiminis G, Hutchinson MR, Mustafa S. Brain Behavior and Immunity (In Press)

Proteome Analysis of Ground State Pluripotency

Taleahmad S, Mirzaei M, Parker LM, Hassani SN, Mollamohammadi S, Sharifi-Zarchi A, Haynes PA, Baharvand H, Salekdeh G. Scientific Reports. Dec 16;5:17985, 2015.

Somatostatin 2A Receptors are not expressed on functionally identified respiratory neurons in the ventral respiratory column of the rat

Le S, Turner AJ, Parker LM, Burke PG, Kumar NN, Goodchild AK, McMullan S. Journal of Comparative Neurology. 524: 1384–1398, 2015

Chronic methamphetamine self-administration dysregulates oxytocin plasma levels and oxytocin receptor fibre density in the nucleus accumbens core and subthalamic nucleus of the rat

Baracz SJ, Parker LM, Suraev AS, Everett NA, Goodchild AK, McGregor IS, Cornish JL. Journal of Neuroendocrinology, 28:4, 2015.

GABAergic mRNA expression is upregulated in the prefrontal cortex of rats sensitized to methamphetamine

Wearne TA, Parker LM, Franklin JL, Goodchild AK, Cornish JL. Behavioral Brain Research. Jan 15;297:224-30, 2015.

Hydralazine administration activates sympathetic preganglionic neurons whose activity mobilizes glucose and increases cardiovascular function

Parker LM, Damanhuri H, Fletcher S, McMullen S, Goodchild AK. Brain Research. 1604:25-34, 2015.   

DDX3Y, a Male Specific Region of Y Chromosome Gene, may modulate neuronal differentiation

Vakilian H, Mirzaei M, Tabar MS, Pooyan P, Rezaee LH, Parker LM, Haynes PA, Gourabi H, H Baharvand, and Salekdeh GH. J. Proteome Res.14 (9), pp 3474–3483, 2015. 

a9

Distribution and neurochemical characterization of neurons in the rat ventrolateral medulla activated by glucoprivation

Parker LM, Kumar NK, Lonergan T, McMullen S, Goodchild AK. Brain Structure and Function. Jan;220(1):117-34, 2013

 

a4

Regional changes in cardiac and stellate ganglion norepinephrine transporter in DOCA-salt hypertension

Wehrwein EA, Novotny M, Swain GM, Parker LM, Esfahanian M, Spitsbergen JM, Habecker BA, and Kreulen DL. Autonomic Neuroscience: Basic and Clinical, 179(1-2):99-107, 2013.

 

a3

Neurochemical codes of sympathetic preganglionic neurons activated by glucoprivation

Parker LM, Kumar NK, Lonergan T, Goodchild AK Journal of Comparative Neurology. 521(12): 2703-18, 2013.

 

a2

Distribution and localization of Gα proteins in the rostral ventrolateral medulla of normotensive and hypertensive rats: focus on catecholaminergic neurons

Parker LM, Tallapragada VJ, Kumar NN, Goodchild AK Neuroscience 218:20-34, 2012.

a5

Neuropeptide coding of sympathetic preganglionic neurons; focus on adrenally projecting populations

Kumar, N.N., Allen, K., Parker, L., Damanhuri, H., Goodchild, A.K. Neuroscience170(3), 789-99, 2010.

a1

Cardiac Norepinephrine Transporter protein is regionally expressed across heart chambers and is inversely correlated tochambernorepinephrine content

Wehrwein EA, Parker LM, Wright AA, Spitsbergen JM, Quaiserova-Mocko V, Novotny M, Swain GM, Kreulen DL.
Am J Physiol Regul Integr Comp Physiol. 295 (3), 2008.

Differential Regulation of NADPH Oxidase in Sympathetic and Sensory Ganglia in Deoxycorticosterone Acetate–Salt Hypertension

Cao X, Dai X, Parker LM, Kreulen DL.
Hypertension 50 (4), pp. 663-671, 2007.