My key research interest has always been to improve our understanding of neural circuitry, neuronal gene expression and neuronal behavior during brain disease and cancer. I completed a PhD in Advanced Medicine in 2014, researching the neurochemistry of the stress response, focusing heavily on understanding cardiovascular related circuitry. I have long held a personal interest in researching cardiovascular disease as I was diagnosed in my teens with an inherited neurogenic cardiovascular disorder and my father died at a young age from cardiovascular disease. My academic experience and research training have provided me the opportunity to understand, in depth, cardiovascular disease progression and the effects of multiple other types of physiological stressors at the systems and cellular levels in the central and peripheral nervous systems.
A 2018 Australian Research Council DECRA Fellow, I currently have 23 peer reviewed publications and an h-index of 10. I am now researching sugar receptor expression in the central nervous system during chronic pain and brain cancer in order to develop new nanotechnology based assays for targeting and measuring affected brain cells. My research will accelerate the development of precision medicine for treating brain disorders, allowing us to treat and measure affected cells more accurately.
As an undergraduate student at the University of California Santa Barbara and then Michigan State University, I was highly interested in understanding how stress hormones affect the brain to produce behavioral outcomes in animals and humans. I completed a Bachelor of Science degree in 2006 in Psychology at Michigan State University. I then worked for two years under Professors David Kreulen and Gregory Fink examining molecular changes in autonomic ganglia during hypertension at Michigan State University. I completed my graduate research with Associate Professor Ann Goodchild understanding molecular mechanisms that contribute to hypertension, hypotension, hypoglycemia and hyperglycemia. Specifically, I used cholera toxin B neuronal tracing in combination with in situ hybridization and immunohistochemistry for neurochemical markers. During the next two years as a post doc I continued researching hypothalamic pituitary axis responses to physiological stressors including describing hyperglycemic responses to common medications prescribed for the treatment of hypertension.
I additionally have collaborated on a number of studies looking at molecular mechanisms involved in the development and extinction of methamphetamine addiction as well as neurochemical identification of circuits regulating brainstem respiratory responses.
My 3 year appointment as a Research Fellow at the ARC Centre of Excellence for Nanoscale BioPhotonics enabled me to facilitate multidisciplinary approaches for studying biological challenges by using innovative technologies to enhance imaging capabilities- making nanoparticles and advanced microscopy techniques understandable and accessible to neuroscientists and other biologists. This includes integrating the latest advancements from the fields of microfluidics, biophysics, materials chemistry and photonics to help neuroscientists solve common challenges presented when imaging brain and spinal cord tissues.
VISUALIZING NEUROINFLAMMATION WITH FLUORESCENCE AND LUMINESCENT LANTHANIDE BASED IN SITU HYBRIDIZATION.
Parker LM, Sayyadi N, Staikopoulos V, Shrestha A, Hutchinson MR, Packer NH (2019). (March 8 In Press Journal of Neuroinflammation)
UNDERSTANDING CELLULAR GLYCAN SURFACES IN THE CENTRAL NERVOUS SYSTEM.
Iqbal S, Ghanimi Fard M, Everest-Dass A, Packer NH, Parker LM (2019). doi:10.1042/BST20180330 (In Press, Biochemical Society Transactions)
THE EFFECT OF STREPTOZOTOCIN-INDUCED HYPERGLYCEMIA ON N-AND O-LINKED PROTEIN GLYCOSYLATION IN MOUSE OVARY.
Shathili AM, Brown HM, Everest-Dass AV, Tan TCY, Parker LM, Thompson JG, Packer NH (2018). Glycobiology 2018. https://doi.org/10.1093/glycob/cwy075.
MICROWAVE PRETREATMENT OF PARAMYLON ENHANCES THE ENZYMATIC PRODUCTION OF SOLUBLE Β 1,3-GLUCANS WITH IMMUNOSTIMULATORY ACTIVITY.
Gissibl A, Care A, Parker LM, Iqbal S, Hobba G, Nevalainen, Sunna A. Carbohydrate Polymers. 2018, 196:339-347. doi: 10.1016/j.carbpol.2018.05.038.
REDUCED BACKGROUND AUTOFLUORESCENCE FOR CELL IMAGING USING NANODIAMONDS AND LANTHANIDE CHELATES.
Cordina NM, Sayyadi N, Parker LM, Zhao Z, Everest-Dass A, Stoodley M, Brown L, Packer NH. Scientific Reports. 2018 Mar 14;8(1):4521. doi: 10.1038/s41598-018-22702-1.
METHAMPHETAMINE-INDUCED BEHAVIOURAL SENSITIZATION INDUCES SPECIFIC INTERNEURONAL MRNA PATHOLOGY ACROSS THE PRELIMBIC AND ORBITOFRONTAL CORTICES.
Wearne TA, Parker LM, Franklin JL, Goodchild AK, Cornish JL (2017). Progress in Neuropsychopharmacology & Biological Psychiatry. Jul 3;77:42-48. doi: 10.1016/j.pnpbp.2017.03.018
QUANTITATIVE PROTEOMIC ANALYSIS OF HUMAN TESTIS REVEALS SYSTEM-WIDE MOLECULAR AND CELLULAR PATHWAYS ASSOCIATED WITH NON-OBSTRUCTIVE AZOOSPERMIA.
Alikhani M, Mirzaei M, Sabbaghian M, Parsamatin P, Karamzadeh R, Adib S, Sodeifi N, Gilani MAS, Zabet-Moghaddam M, Parker LM, Wo Y, Haynes PA, Gourabi H, Baharvand H, and Salekdeh GH (2017). Journal of Proteomics Jun 6;162:141-154. doi: 10.1016/j.jprot.2017.02.007
NEUROCHEMISTRY OF NEURONS IN THE VENTROLATERAL MEDULLA ACTIVATED BY HYPOTENSION: ARE THE SAME NEURONS ACTIVATED BY GLUCOPRIVATION?
Parker LM, Le S, Wearne T, Hardwick K, Kumar NN, Robinson KJ, McMullan S, Goodchild AK (2017). Journal of Comparative Neurology Jun 15;525(9):2249-2264. doi: 10.1002/cne.24203.
GABAERGIC MRNA EXPRESSION IS DIFFERENTIALLY EXPRESSED ACROSS THE PRELIMBIC AND ORBITOFRONTAL CORTICES OF RATS SENSITIZED TO METHAMPHETAMINE: RELEVANCE TO PSYCHOSIS.
Wearne TA, Parker LM, Franklin JL, Goodchild AK, Cornish JL (2016). Neuropharmacology, 111, 107-118 doi:10.1016/j.neuropharm.2016.08.038
BRIGHTNESS AND PHOTOSTABILITY OF EMERGING RED AND NEAR-IR FLUORESCENT NANOMATERIALS FOR BIOIMAGING.
Reineck P, Francis A, Orth A, Lau DWM, Nixon-Luke RDV, Rastogi ID, Razali WAW, Cordina NM, Parker LM, Sreenivasan VKA, Brown LJ, Gibson BC (2016). Advanced Optical Materials. 4(10): p. 1549-1557 doi:10.1002/adom.201600212
Novel imaging tools for investigating the role of immune signaling in the brain
Jacobsen JHW, Parker LM, Staikopoulos V, Schartner E, Tsiminis G, Hutchinson MR, Mustafa S. Brain Behavior and Immunity (In Press)
Proteome Analysis of Ground State Pluripotency
Taleahmad S, Mirzaei M, Parker LM, Hassani SN, Mollamohammadi S, Sharifi-Zarchi A, Haynes PA, Baharvand H, Salekdeh G. Scientific Reports. Dec 16;5:17985, 2015.
Somatostatin 2A Receptors are not expressed on functionally identified respiratory neurons in the ventral respiratory column of the rat
Le S, Turner AJ, Parker LM, Burke PG, Kumar NN, Goodchild AK, McMullan S. Journal of Comparative Neurology. 524: 1384–1398, 2015
Chronic methamphetamine self-administration dysregulates oxytocin plasma levels and oxytocin receptor fibre density in the nucleus accumbens core and subthalamic nucleus of the rat
Baracz SJ, Parker LM, Suraev AS, Everett NA, Goodchild AK, McGregor IS, Cornish JL. JJournal of Neuroendocrinology, 28:4, 2015.
GABAergic mRNA expression is upregulated in the prefrontal cortex of rats sensitized to methamphetamine
Wearne TA, Parker LM, Franklin JL, Goodchild AK, Cornish JL. Behavioral Brain Research. Jan 15;297:224-30, 2015.
Hydralazine administration activates sympathetic preganglionic neurons whose activity mobilizes glucose and increases cardiovascular function